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Science in Kempenhaeghe

In addition to care and education Kempenhaeghe also focuses on the development of know-how and expertise in epileptology, sleep medicine and neurocognition. ‘TriO’ is the organ that safeguards research, development and education for the five Kempenhaeghe centers. Multidisciplinary, thematic research groups research strategically selected themes.

Scientific research in Kempenhaeghe originates and is inspired in the practice of specialized care and specialized education. The number of research projects in which we are involved, publications and doctoral research, continues to grow. Together we develop new perspectives that result in the ever-increasing improvement of patient care and deepening of our know-how of the disorders. This is how we invest in the quality of our care, diagnostics, treatment and support and how we spread our know-how.

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Cooperating in networks

Via cooperation and academization we realize and safeguard the scientific yield in our areas of expertise. We work nationally and internationally with universities, other academic centers, knowledge institutes and corporations. Several specialists who work in Kempenhaeghe are professor at universities in the Netherlands and Belgium.

Together with Maastricht UMC+, Kempenhaeghe is the Academic Center for Epileptology, that maintains close ties with UZ Gent. In a strong combination with the University of Technology Eindhoven we focus on science and innovation. The Center for Sleep Medicine, the Center for Neurological Learning and Development Disabilities and the Center for Residential Epilepsy Care also develop and embed expertise with these parties.

In the field of epilepsy there are ties with Radboudumc and UMC Utrecht. In sleep research we work together with Radboudumc and CIRO. In the field of learning disorders there are contacts with Leiden UMC and Erasmus MC. Those contacts also exist between the Center for Residential Epilepsy Care and ErasmusMC.  Moreover, we participate in – mostly together with the aforementioned academic hospitals – in various consortiums in the Netherlands and in Europe.

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Chairs and research lines

The professors linked to Kempenhaeghe are the top specialists in their area of expertise. They establish connections between Kempenhaeghe and university centers and promote the presence of Kempenhaeghe in the best national and international research networks.

In consultation with the management teams of the Kempenhaeghe centers they initiate research lines and supervise and coordinate scientific projects. They also teach at universities and contribute to the transfer of expertise as chairperson or speaker on congresses in the Netherlands and abroad. The professors are also active in the direct care for patients, which contributes to safeguarding the link between science and the daily care practice.

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Scientific researchers

In Kempenhaeghe many staff members are active in scientific research.

A large group of PhD students is fulltime employed at universities, working on research projects in which Kempenhaeghe is involved. Doctorate senior researchers with double assignments work both at the University of Technology Eindhoven and in Kempenhaeghe, researching our areas of expertise.

In addition, several practitioners in Kempenhaeghe work part-time on their doctoral research. Following their doctorate trajectory these practitioners remain active in Kempenhaeghe in scientific projects in their (clinical) area of expertise. They also contribute to the development and transfer of expertise via publications and presentations.

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Publications*

  • Last 6 months, monthly update. Looking for a specific article? Please refer to Pubmed

Padsevonil randomized phase IIa trial in treatment-resistant focal epilepsy – a translational approach.

Auteurs Muglia P, Hannestad J, Brandt C, De Bruyn S, Germani M, Lacroix B, Majoie M, Otoul C, Sciberras D, Steinhoff BJ, Van Laere K, Van Paesschen W, Webster E, Kaminski RM, Werhahn KJ, Toledo M.
Reeks Brain Communication. 2020; Nov 2. doi: 10.1093/braincomms/fcaa183
Datum 02-11-2020 View publication

Obstructive sleep apnea in people with intellectual disabilities: adherence to and effect of CPAP

Auteurs van den Broek N, Broer L, Vandenbussche N, Tan I, Overeem S, Pillen S.
Reeks Sleep Breath. 2020 Oct 21. doi: 10.1007/s11325-020-02221-y. Epub ahead of print.
Datum 21-10-2020 View publication

Recommendations for the treatment of epilepsy in adult and pediatric patients in Belgium: 2020 update

Auteurs Boon P, Ferrao Santos S, Jansen AC, Lagae L, Legros B, Weckhuysen S.
Reeks Acta Neurol Belg. 2020 Oct 13. doi: 10.1007/s13760-020-01488-y. Epub ahead of print
Datum 13-10-2020 View publication

Model-Based Evaluation of Methods for Respiratory Sinus Arrhythmia Estimation

Auteurs MoralesTellez JF, Moeyersons J, Armanac P, Orini M, Faes L, Overeem S, Van Gilst M, Van Dijk J, Huffel SV, Bailon R, Varon C
Reeks IEEE Trans Biomed Eng. 2020 Oct 1;PP. doi: 10.1109/TBME.2020.3028204. Epub ahead of print
Datum 01-10-2020 View publication

The Neurocognitive and Behavioral Profiles of 3 Brothers With Becker Muscular Dystrophy

Auteurs Hellebrekers DM, Vles JS, Klinkenberg S, Hendriksen JG
Reeks Child Neurology Open 2020; 7: 1-5. doi: 10.1177/2329048X20957217 Epub ahead of print
Datum 25-09-2020 View publication

Development of a Rat Model for Glioma-Related Epilepsy

Auteurs Bouckaert C, Germonpré C, Verhoeven J, Chong SA, Jacquin L, Mairet-Coello G, André VM, Leclercq K, Vanhove C, De Vos F, Van den Broecke C, Goethals I, Descamps B, Donche S, Carrette E, Wadman W, Boon P, Vonck K, Raedt R
Reeks Int J Mol Sci. 2020 Sep 23;21(19):E6999. doi: 10.3390/ijms21196999.
Datum 23-09-2020 View publication

249th ENMC International Workshop: The role of brain dystrophin in muscular dystrophy: Implications for clinical care and translational research, Hoofddorp, The Netherlands, November 29th-December 1st 2019

Auteurs Hendriksen JGM, Thangarajh M, Kan HE, Muntoni F, ENMC 249th workshop study group
Reeks Neuromuscul Disord 2020; 30(9): 782-794. doi: 10.1016/j.nmd.2020.08.357.
Datum 20-09-2020 View publication

Assessing sleep-wake survival dynamics in relation to sleep quality in a placebo-controlled pharmacological intervention study with people with insomnia and healthy controls

Auteurs Hermans LWA, Regis M, Fonseca P, Overeem S, Leufkens TRM, Vermeeren A, van Gilst MM.
Reeks Psychopharmacology (Berl). 2020 Sep 17. doi: 10.1007/s00213-020-05660-3. Epub ahead of print.
Datum 17-09-2020 View publication

A Comprehensive View on MRI Techniques for Imaging Blood-Brain Barrier Integrity.

Auteurs Elschot EP, Backes WH, Postma AA, van Oostenbrugge RJ, Staals J, Rouhl RPW, Jansen JFA. A
Reeks Invest Radiol. 2020 Sep 15. doi: 10.1097/RLI.0000000000000723. Epub ahead of print.
Datum 15-09-2020 View publication

Four-Year Follow-up of [18 F]Fluorodeoxyglucose Positron Emission Tomography-Based Parkinson's Disease-Related Pattern Expression in 20 Patients With Isolated Rapid Eye Movement Sleep Behavior Disorder Shows Prodromal Progression.

Auteurs Kogan RV, Janzen A, Meles SK, Sittig E, Renken RJ, Gurvits V, Mayer G, Leenders KL, Oertel WH; REMPET Working Group (o.a. Overeem S, Pijpers A)
Reeks Mov Disord. 2020 Sep 10. doi: 10.1002/mds.28260. Epub ahead of print.
Datum 10-09-2020 View publication

New 2013 incidence peak in childhood narcolepsy: more than vaccination?

Auteurs Zhang Z, Gool J, Fronczek R, Dauvilliers Y, Bassetti CLA, Mayer G, Plazzi G, Pizza F, Santamaria J, Partinen M, Overeem S, Peraita-Adrados R, da Silva AM, Sonka K, Del Rio-Villegas R, Heinzer R, Wierzbicka A, Young P, Högl B, Manconi M, Feketeova E, Mathi
Reeks Sleep. 2020 Sep 10:zsaa172. doi: 10.1093/sleep/zsaa172. Epub ahead of print.
Datum 10-09-2020 View publication

Prevalence and incidence of vertebral fractures: a 7-year follow-up study in institutionalized adults with refractory epilepsy and intellectual disability

Auteurs Berkvens J, Majoie M, Mergler S, Beerhorst K, Verschuure P, Tan I, den Bergh JV.
Reeks Epilepsy Res. 2020 Sep 10;167:106461. doi: 10.1016/j.eplepsyres.2020.106461. Epub ahead of print.
Datum 10-09-2020 View publication

Localization of deep brain activity with scalp and subdural EEG

Auteurs Fahimi Hnazaee M, Wittevrongel B, Khachatryan E, Libert A, Carrette E, Dauwe I, Meurs A, Boon P, Van Roost D, Van Hulle MM
Reeks Neuroimage. 2020 Sep 6;223:117344. doi: 10.1016/j.neuroimage.2020.117344. Epub ahead of print
Datum 06-09-2020 View publication

High-gamma oscillations precede visual steady-state responses: A human electrocorticography study.

Auteurs Wittevrongel B, Khachatryan E, Carrette E, Boon P, Meurs A, Van Roost D, Van Hulle MM
Reeks Hum Brain Mapp. 2020 Sep 4. doi: 10.1002/hbm.25196. Epub ahead of print.
Datum 04-09-2020 View publication

Deep Brain Stimulation in Epilepsy: A Role for Modulation of the Mammillothalamic Tract in Seizure Control?

Auteurs Schaper FLWVJ, Plantinga BR, Colon AJ, Wagner GL, Boon P, Blom N, Gommer ED, Hoogland G, Ackermans L, Rouhl RPW, Temel Y.
Reeks Neurosurgery. 2020 Sep 1;87(3):602-610. doi: 10.1093/neuros/nyaa141
Datum 01-09-2020 View publication

Comparative Review of the Algorithms for Removal of Electrocardiographic Interference from Trunk Electromyography

Auteurs Xu L, Peri E, Vullings R, Rabotti C, Van Dijk JP, Mischi M.
Reeks Sensors (Basel). 2020 Aug 29;20(17):E4890. doi: 10.3390/s20174890.
Datum 29-08-2020 View publication

Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

Auteurs Lamberink HJ, Otte WM, Blümcke I, Braun KPJ, European Epilepsy Brain Bank writing group, study group (collaborators o.a. O. Schijns), European Reference Network EpiCARE
Reeks Lancet Neurol. 2020 Sep;19(9):748-757
Datum 27-08-2020 View publication

24-hour activity for children with cerebral palsy: a clinicalpractice guide

Auteurs Verschuren O, Hulst RY, Voorman J, Pillen S, Luitwieler N, Dudink J, Gorter JW
Reeks Dev Med Child Neurol. 2020 Aug 27. doi: 10.1111/dmcn.14654. Epub ahead of print.
Datum 27-08-2020 View publication

Effects of long-term sleep disruption on cognitive function and brain amyloid-β burden: a case-control study

Auteurs Thomas J, Ooms SJ, Mentink LJ, Booij J, Olde Rikkert MGM, Overeem S, Kessels RPC, Claassen J.
Reeks Alzheimers Res Ther. 2020 Aug 26;12(1):101. doi: 10.1186/s13195-020-00668-5.
Datum 26-08-2020 View publication

European Expert Opinion on ANT-DBS therapy for patients with drug-resistant epilepsy (a Delphi consensus).

Auteurs Kaufmann E, Bartolomei F, Boon P, Chabardes S, Colon AJ, Eross L, Fabó D, Gonçalves-Ferreira A, Imbach LL, Van Paesschen W, Peltola J, Rego R, Theys T, Voges B
Reeks Seizure. 2020 Aug 22;81:201-209. doi: 10.1016/j.seizure.2020.08.015. Epub ahead of print.
Datum 22-08-2020 View publication

Computationally-Efficient Algorithm for Real-Time Absence Seizure Detection in Wearable Electroencephalography

Auteurs Dan J, Vandendriessche B, Van Paesschen W, Weckhuysen D, Bertrand A
Reeks Int J Neural Syst. 2020 Aug 18:2050035. doi: 10.1142/S0129065720500355. Epub ahead of print
Datum 18-08-2020 View publication

Wearable monitoring of sleep-disordered breathing: estimation of the apnea-hypopnea index using wrist-worn reflective photoplethysmography

Auteurs Papini GB, Fonseca P, van Gilst MM, Bergmans JWM, Vullings R, Overeem S.
Reeks Sci Rep. 2020;10(1):13512. Published 2020 Aug 11. doi:10.1038/s41598-020-69935-7
Datum 11-08-2020 View publication

Mortality of all causes and sudden unexplained death in epilepsy (SUDEP) in a cohort of 235 persons living with epilepsy in Rwanda using WHO Verbal Autopsy Questionnaire

Auteurs Sebera F, Uwacu BH, Nsanzabaganwa W, Umwiringirwa J, Dedeken P, Teuwen DE, Boon PAJM
Reeks Epilepsy Behav Rep. 2020 Jul 30;14:100383. doi: 10.1016/j.ebr.2020.100383
Datum 30-07-2020 View publication

Sleep Health Practices and Sleep Knowledge among Healthcare Professionals in Dutch Paediatric Rehabilitation.

Auteurs Hulst RY, Pillen S, Voorman JM, Rave N, Visser-Meily JMA, Verschuren O
Reeks Child Care Health Dev. 2020 Jul 24. doi: 10.1111/cch.12799. Epub ahead of print
Datum 24-07-2020 View publication

The importance of specialized sleep investigations in children with a suprasellar tumor.

Auteurs van Schaik J, Pillen S, van Litsenburg RRL, Vandenbussche NLE, de Bont JM, Schouten-van Meeteren AYN, van Santen HM.
Reeks Pituitary. 2020 Jul 20. doi: 10.1007/s11102-020-01065-9. Epub ahead of print.
Datum 20-07-2020 View publication

Freezing of gait detection in Parkinson’s disease via multimodal analysis of EEG and accelerometer signals.

Auteurs Wang Y, Beuving F, Nonnekes J, Cohen MX, Long X, Aarts RM, van Wezel R
Reeks 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC): IEEE, p 847-850
Datum 20-07-2020 View publication

Unidentified Neuronal Surface IgG Autoantibodies in a Case of Hashimoto's Encephalopathy

Auteurs Mane-Damas M, NeuronalVinke A, Hoffmann C, Zong S, Losen M, Molenaar PC, Damoiseaux J, Koudijs S, Rouhl RPW, Martinez-Martinez P.
Reeks Front Immunol. 2020 Jul 7;11:1358. doi: 10.3389/fimmu.2020.01358
Datum 07-07-2020 View publication

Neurocognitive and behavioural profile in Panayiotopoulos syndrome

Auteurs Fonseca Wald ELA, Debeij-Van Hall MHJA, De Jong E, Aldenkamp AP, Vermeulen RJ, Vles JSH, Klinkenberg S, Hendriksen JGM.
Reeks Dev Med Child Neurol. 2020 Aug;62(8):985-992. doi: 10.1111/dmcn.14417. Epub 2019 Dec 3.
Datum 01-07-2020 View publication

Shedding light on human cerebral lipofuscin: An explorative study on identification and quantification.

Auteurs Hakvoort K, Otto L, Haeren R, Hoogland G, Schijns O, Vink H, Klein D, van Zandvoort M, Rijkers K.
Reeks J Comp Neurol. 2020 Jun 27. doi: 10.1002/cne.24971. [Epub ahead of print]
Datum 27-06-2020 View publication

Early Infantile Epileptic Encephalopathy Due to Biallelic Pathogenic Variants in PIGQ: Report of 7 New Subjects and Review of the Literature

Auteurs Johnstone DL, Nguyen TTM, Zambonin J, Kernohan KD, St-Denis A, Baratang NV, Hartley T, Geraghty MT, Richer J, Majewski J, Bareke E, Guerin A, Pendziwiat M, Pena LDM, Braakman HMH, Grip KW, Edmondson AC, He M, Spillmann RC, Eklund EA, Bayat A, Network UD;
Reeks J Inherit Metab Dis. 2020 Jun 26. doi: 10.1002/jimd.12278. Epub ahead of print
Datum 26-06-2020 View publication

Sensitivity of magnetoencephalography as a diagnostic tool for epilepsy: a prospective study.

Auteurs Koster I, Ossenblok P, Brekelmans GJ, van der Linden I, Hillebrand A, Wijnen BF, Colon AJ
Reeks Epileptic Disord. 2020;22(3):264-272. doi:10.1684/epd.2020.1160
Datum 15-06-2020 View publication

Shift-work-related sleep disruption and the risk of decline in cognitive function: The CRUISE Study.

Auteurs Thomas J, Overeem S, Dresler M, Kessels RPC, Claassen JAHR.
Reeks J Sleep Res. 2020 Jun 8:e13068. doi: 10.1111/jsr.13068. [Epub ahead of print]
Datum 08-06-2020 View publication

Effect of treatment on cognitive and attention problems in children with narcolepsy type 1.

Auteurs Janssens KAM, Quaedackers L, Lammers GJ, Amesz P, van Mierlo P, Aarts L, Peeters E, Hendriks D, Vandenbussche N, Overeem S, Pillen S.
Reeks Sleep. 2020 Jun 6. pii: zsaa114. doi: 10.1093/sleep/zsaa114. [Epub ahead of print]
Datum 06-06-2020 View publication

Accelerated Cognitive Ageing in epilepsy: exploring the effective connectivity between resting-state networks and its relation to cognitive decline

Auteurs Bernas A, Breuer LEM, Lamerichs R, de Louw AJA, Aldenkamp AP, Zinger S
Reeks Heliyon 2020 6(6) e03951
Datum 05-06-2020 View publication

Variability in the analysis of a single neuroimaging dataset by many teams.

Auteurs Botvinik-Nezer R, Holzmeister F, Camerer CF, Dreber A, Huber J, Johannesson M, Kirchler M, Iwanir R, Mumford JA,... Heunis S [et al]
Reeks Nature. 2020 Jun;582(7810):84-88. doi: 10.1038/s41586-020-2314-9. Epub 2020 May 20.
Datum 01-06-2020 View publication

Volumetric and Functional Activity Lateralization in Healthy Subjects and Patients with Focal Epilepsy: Initial Findings in a 7T MRI Study

Auteurs Canjels LPW, Backes WH, van Veenendaal TM, Vlooswijk MCG, Hofman PAM, Aldenkamp AP, Rouhl RPW, Jansen JFA.
Reeks J Neuroimaging. 2020 May 30. doi: 10.1111/jon.12739. [Epub ahead of print]
Datum 30-05-2020 View publication

Respiratory Activity Extracted From Wrist-Worn Reflective Photoplethysmography in a Sleep-Disordered Population

Auteurs Papini GB, Fonseca P, van Gilst MM, Bergmans JWM, Vullings R, Overeem S
Reeks Physiol Meas. 2020 May 19. doi: 10.1088/1361-6579/ab9481. Epub ahead of print.
Datum 19-05-2020 View publication

European perspective of perampanel response in people with Intellectual Disability.

Auteurs Allard J, Henley W, Snoeijen-Schouwenaars F, van Ool J, Tan I, Schelhaas HJ, Majoie MHJM, Hudson S, McLean B, Shankar R.
Reeks Acta Neurol Scand. 2020 May 8. doi: 10.1111/ane.13261. [Epub ahead of print]
Datum 08-05-2020 View publication

Automated video-based detection of nocturnal motor seizures in children.

Auteurs van Westrhenen A, Petkov G, Kalitzin SN, Lazeron RHC, Thijs RD.
Reeks Epilepsia. 2020 May 7. doi: 10.1111/epi.16504. [Epub ahead of print]
Datum 07-05-2020 View publication

Augmenting interictal mapping with neurovascular coupling biomarkers by structured factorization of epileptic EEG and fMRI data

Auteurs Van Eyndhoven S, Dupont P, Tousseyn S, Vervliet N, Van Paesschen W, Van Huffel S, Hunyadi B
Reeks arXiv preprint arXiv:2004.14185 [eess.SP]
Datum 06-05-2020 View publication

Prescription Drugs Used in Insomnia

Auteurs Dujardin S, Pijpers A, Pevernagie D
Reeks Sleep Med Clin. 2020 Jun;15(2):133-145. doi: 10.1016/j.jsmc.2020.02.002.
Datum 05-05-2020 View publication

Quality and denoising in real‐time functional magnetic resonance imaging neurofeedback: A methods review

Auteurs Heunis S, Lamerichs R, Zinger S, Caballero-Gaudes C, Jansen JFA, Aldenkamp B, Breeuwer M
Reeks Hum Brain Mapp. 2020 Apr 25. doi: 10.1002/hbm.25010. [Epub ahead of print]
Datum 25-04-2020 View publication

Functional brain network characteristics are associated with epilepsy severity in childhood absence epilepsy

Auteurs Drenthen GS, Fasen F, Fonseca Wald ELA, Backes WH, Aldenkamp AP, Vermeulen RJ, Debeij-van Hall M, Hendriksen J, Klinkenberg S, Jansen JF
Reeks Neuroimage Clin 2020 Apr 23 doi: 10.1016/j.nicl.2020.102264 [Epub ahead of print]
Datum 23-04-2020 View publication

False alarms reduction in non-convulsive status epilepticus detection via continuous EEG analysis.

Auteurs Wang Y, Long X, van Dijk H, Aarts RM, Wang L, Arends JBAM.
Reeks Physiol Meas. 2020 Apr 23. doi: 10.1088/1361-6579/ab8cb3. [Epub ahead of print]
Datum 23-04-2020 View publication

Breath analysis in detecting epilepsy.

Auteurs van Dartel D, Schelhaas J, Colon A, Kho K, de Vos C.
Reeks J Breath Res. 2020 Apr 15;14(3):031001. doi: 10.1088/1752-7163/ab6f14.
Datum 15-04-2020 View publication

Effectiveness and tolerability of adjunctive brivaracetam in patients with focal seizures: second interim analysis of 6-month data from a prospective observational study in Europe

Auteurs Steinhoff BJ, Christoensen J, Doherty CP, Majoie M, De Backer M, Hellot S, Leunikava I, Leach JP
Reeks Epilepsy Res. 2020 Apr 9. doi: 10.1016/j.eplepsyres.2020.106329. [Epub ahead of print]
Datum 09-04-2020 View publication

Epilepsy phenotype in individuals with chromosomal duplication encompassing FGF12

Auteurs Willemsen MH, Goei H, Verhoeven JS, Braakman H, de Leeuw N, Freeth A, Miniassian BA
Reeks Epilepsia Open. Apr 8. doi: 10.1002/epi4.12396. [Epub ahead of print]
Datum 08-04-2020 View publication

Constructing an Axonal-Specific Myelin Developmental Graph and its Application to Childhood Absence Epilepsy.

Auteurs Drenthen GS, Fonseca Wald ELA, Backes WH, Aldenkamp AP, Vermeulen RJ, Debeij-van Hall MHJA, Klinkenberg S, Jansen JFA.
Reeks J Neuroimaging. 2020 Apr 7. doi: 10.1111/jon.12707. [Epub ahead of print]
Datum 07-04-2020 View publication

Automatic sleep staging using heart rate variability, body movements, and recurrent neural networks in a sleep disordered population

Auteurs Fonseca P, van Gilst MM, Radha M, Ross M, Moreau A, Cerny A, Anderer P, Long X, van Dijk JP, Overeem S.
Reeks Sleep. 2020 Apr 6. pii: zsaa048. doi: 10.1093/sleep/zsaa048. [Epub ahead of print]
Datum 06-04-2020 View publication